BSJ-03-123
BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
Product Specifications
CAS Number
[2361493-16-3]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BSJ-03-123.html
Purity
99.19
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(C(C)=O)=C1C)N(C2CCCC2)C3=C1C=NC(NC4=CC=C(N5CCN(CCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=O)CC5)C=N4)=N3
Molecular Formula
C47H56N10O11
Molecular Weight
937.01
Precautions
H302, H312, H332
References & Citations
[1]Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26 (2) :300-306.e9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK6; Cereblon
Available Sizes
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