Esuprone
Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research[1][2].
Product Specifications
CAS Number
91406-11-0
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/esuprone.html
Purity
99.55
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(OS(CC)(=O)=O)C=C1O2)=C(C)C2=O
Molecular Formula
C13H14O5S
Molecular Weight
282.31
References & Citations
[1]Löscher W, et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288 (3) :984-92.|[2]Bergström M, et al. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52 (2) :121-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MAO-A
Available Sizes
Frequently Asked Questions
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