Esuprone

Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research[1][2].

Product Specifications

CAS Number

[91406-11-0]

UNSPSC

12352005

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/esuprone.html

Purity

99.55

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(OS(CC)(=O)=O)C=C1O2)=C(C)C2=O

Molecular Formula

C13H14O5S

Molecular Weight

282.31

References & Citations

[1]Löscher W, et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288 (3) :984-92.|[2]Bergström M, et al. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52 (2) :121-8.