Reproxalap
Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis[1][2][3][4][5].
Product Specifications
CAS Number
916056-79-6
Product Name Alternative
ADX-102; NS-2
UNSPSC
12352005
Hazard Statement
H303, H313, H315, H319, H333, H335
Target
Caspase; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/reproxalap.html
Purity
98.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=NC2=C(C=C(Cl)C=C2)C=C1N)(O)C
Molecular Formula
C12H13ClN2O
Molecular Weight
236.70
Precautions
H303, H313, H315, H319, H333, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Caspase 3; Caspase 7; PKCα
Available Sizes
Frequently Asked Questions
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