Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Reproxalap

Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis[1][2][3][4][5].

Product Specifications

CAS Number

916056-79-6

Product Name Alternative

ADX-102; NS-2

UNSPSC

12352005

Hazard Statement

H303, H313, H315, H319, H333, H335

Target

Caspase; PKC

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/reproxalap.html

Purity

98.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=NC2=C(C=C(Cl)C=C2)C=C1N)(O)C

Molecular Formula

C12H13ClN2O

Molecular Weight

236.70

Precautions

H303, H313, H315, H319, H333, H335

References & Citations

[1]Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.|[2]Reproxalap Phase 2b Dry Eye Disease Results.|[3]Susan G. Macdonald, Ph.D., et al. Novel Small Molecule Aldehyde Sequestering Agents Demonstrate Broad Therapeutic Potential for Ocular Inflammation.|[4]Ochoa CA, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022 Mar 2;12 (3) :393.|[5]Rizzo WB, et al. Sjögren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents. Mol Genet Metab Rep. 2021 Dec 23;30:100839.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

Caspase 3; Caspase 7; PKCα

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

RFC4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1A8]
TA506183AM 100 µL

RFC4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1A8]

Sign In for Pricing
View Details
Orthopedics tractor rack BOPT-403
BOPT-403 1 Unit

Orthopedics tractor rack BOPT-403

Sign In for Pricing
View Details
(S)-Indoxacarb
TRC-I654010-250MG 250 mg

(S)-Indoxacarb

Sign In for Pricing
View Details
GLI4 Mouse Monoclonal Antibody [Clone ID: OTI2E8]
CF806231 100 µg

GLI4 Mouse Monoclonal Antibody [Clone ID: OTI2E8]

Sign In for Pricing
View Details
Thyroglobulin (TG) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1B2]
TA803993BM 100 µL

Thyroglobulin (TG) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1B2]

Sign In for Pricing
View Details
Psoralen TMP Succinimidyl Ester
39060-AAT 5 mg

Psoralen TMP Succinimidyl Ester

Sign In for Pricing
View Details