Prenylamine (lactate)

Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588) . Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents[1].

Product Specifications

CAS Number

[69-43-2]

UNSPSC

12352005

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/prenylamine-lactate.html

Smiles

CC(CC1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.OC(C(O)=O)C

Molecular Formula

C27H33NO3

Molecular Weight

419.56

References & Citations

[1]Bayer R, et al. Basic mechanisms underlying prenylamine-induced ‘torsade de pointes’: differences between prenylamine and fendiline due to basic actions of the isomers[J]. Current Medical Research and Opinion, 1988, 11 (4) : 254-272.