Prenylamine (lactate)
Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588) . Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents[1].
Product Specifications
CAS Number
[69-43-2]
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/prenylamine-lactate.html
Smiles
CC(CC1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.OC(C(O)=O)C
Molecular Formula
C27H33NO3
Molecular Weight
419.56
References & Citations
[1]Bayer R, et al. Basic mechanisms underlying prenylamine-induced ‘torsade de pointes’: differences between prenylamine and fendiline due to basic actions of the isomers[J]. Current Medical Research and Opinion, 1988, 11 (4) : 254-272.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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