ST271
ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
Product Specifications
CAS Number
106392-48-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ST271.html
Purity
98.00
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1
Molecular Formula
C16H20N2O2
Molecular Weight
272.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand) . 1994 Jul;40 (5) :627-34.|[2]Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.|[3]Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt 3) :597-600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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