ST271

ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.

Product Specifications

CAS Number

[106392-48-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ST271.html

Purity

98.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N)/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1

Molecular Formula

C16H20N2O2

Molecular Weight

272.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand) . 1994 Jul;40 (5) :627-34.|[2]Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.|[3]Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt 3) :597-600.