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BOC-FlFlF

BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation[1][2].

Product Specifications

CAS Number

66556-73-8

Product Name Alternative

BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe

UNSPSC

12352209

Target

Formyl Peptide Receptor (FPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/boc-phe-leu-phe-leu-phe.html

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CC1=CC=CC=C1)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CC(C)C)NC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)=O)=O)=O

Molecular Formula

C44H59N5O8

Molecular Weight

785.97

References & Citations

[1]Hayashi R, et al. Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH. Bioorg Med Chem. 2014 Aug 1;22 (15) :3824-8. |[2]Stenfeldt AL, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30 (6) :224-9.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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