ELA-11 (human)
ELA-11 (human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].
Product Specifications
CAS Number
1784687-32-6
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; Arrestin
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ela-11-human.html
Purity
99.54
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4N(CCC4)C([C@H](CCSC)NC([C@@H](N)CS)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O
Molecular Formula
C58H90N16O13S2
Molecular Weight
1283.56
References & Citations
[1]Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135 (12) :1160-1173.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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