STING Degrader-1
STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sting-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(N2CCN(C(/C=C/C(C3=CC=C(OC)C=C3)=O)=O)CC2)C=C1)C4=CC=C([N+]([O-])=O)O4
Molecular Formula
C26H24N4O7
Molecular Weight
504.49
References & Citations
[1]Miki Nakamura, et al. Development of STING degrader with double covalent ligands. Bioorg Med Chem Lett. 2024 Feb 24:102:129677.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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