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SIRT-IN-2

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 nM, respectively.

Product Specifications

CAS Number

1431411-66-3

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SIRT-IN-2.html

Purity

98.08

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

NC(C1=CC2=NC=NC(N3CCC(CCNS(C)(=O)=O)CC3)=C2S1)=O

Molecular Formula

C15H21N5O3S2

Molecular Weight

383.49

References & Citations

[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56 (9) :3666-79.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1; SIRT2; SIRT3

Available Sizes

Frequently Asked Questions

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