SIRT-IN-2
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 nM, respectively.
Product Specifications
CAS Number
[1431411-66-3]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SIRT-IN-2.html
Purity
98.08
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
NC(C1=CC2=NC=NC(N3CCC(CCNS(C)(=O)=O)CC3)=C2S1)=O
Molecular Formula
C15H21N5O3S2
Molecular Weight
383.49
References & Citations
[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56 (9) :3666-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
Curated Selection
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