ISX-9

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1][2][3].

Product Specifications

CAS Number

[832115-62-5]

Product Name Alternative

Isoxazole 9

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ISX-9.html

Concentration

10mM

Purity

99.19

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3

Molecular Formula

C11H10N2O2S

Molecular Weight

234.27

Precautions

H315, H319, H335

References & Citations

[1]Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26 (8) :3148-3162.|[2]Jay W Schneider, et al. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul;4 (7) :408-10.|[3]Jamie L Russell, et al. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7 (6) :1067-76.