ALLO-2
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].
Product Specifications
CAS Number
1357350-60-7
Product Name Alternative
trans-4-Aminocrotonic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/allo-2.html
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
Molecular Formula
C18H12F3N5O
Molecular Weight
371.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18 (4) :432-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
349250 1 Kit
Genesig Real-Time PCR detection kit for Listeria monocytogenes, Standard
Sign In for Pricing
View Details 
MBS656932-01 0.1 mg
Apolipoprotein C-III, Human (Apolipoprotein CIII, Apo CIII, Apo C-III, ApoC III, ApoCIII, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC 3, APOC3, MGC150353)
Sign In for Pricing
View Details MBS656932-02 5x 0.1 mg
Apolipoprotein C-III, Human (Apolipoprotein CIII, Apo CIII, Apo C-III, ApoC III, ApoCIII, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC 3, APOC3, MGC150353)
Sign In for Pricing
View Details