ALLO-2

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

Product Specifications

CAS Number

[1357350-60-7]

Product Name Alternative

trans-4-Aminocrotonic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/allo-2.html

Purity

99.72

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F

Molecular Formula

C18H12F3N5O

Molecular Weight

371.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18 (4) :432-7.