4-Bromo-3-hydroxybenzoic acid

4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].

Product Specifications

CAS Number

[14348-38-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-bromo-3-hydroxybenzoic-acid.html

Concentration

10mM

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(Br)C(O)=C1

Molecular Formula

C7H5BrO3

Molecular Weight

217.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22 (8) :939-47.|[2]Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67 (3) :411-417.