Antagonist G

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].

Product Specifications

CAS Number

[115150-59-9]

UNSPSC

12352209

Target

Apoptosis; Vasopressin Receptor

Type

Peptides

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/antagonist-g.html

Purity

99.05

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)N(C([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCCNC(N)=N)N)=O)=O)C)=O)=O)=O

Molecular Formula

C49H66N12O6S

Molecular Weight

951.19

References & Citations

[1]P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50 (13) :3968-73.|[2]A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83 (7) : 941–948.