IMR-1

IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].

Product Specifications

CAS Number

[310456-65-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Notch

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IMR-1.html

Purity

98.95

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

Molecular Formula

C15H15NO5S2

Molecular Weight

353.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76 (12) :3593-603.