Sarpogrelate (hydrochloride)

Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].

Product Specifications

CAS Number

[135159-51-2]

Product Name Alternative

MCI-9042

UNSPSC

12352005

Hazard Statement

H302, H410

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Sarpogrelate-hydrochloride.html

Concentration

10mM

Purity

99.09

Solubility

DMSO : ≥ 62 mg/mL|H2O : 33.33 mg/mL (ultrasonic)

Smiles

COC1=CC=CC(CCC2=CC=CC=C2OCC(CN(C)C)OC(CCC(O)=O)=O)=C1.Cl

Molecular Formula

C24H32ClNO6

Molecular Weight

465.97

Precautions

H302, H410

References & Citations

[1]Rashid M, et al. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 2003 May 30;73 (2) :193-207.|[2]Maruyama K, et al. MCI-9042: high affinity for serotonergic receptors as assessed by radioligand binding assay. J Pharmacobiodyn. 1991 Apr;14 (4) :177-81.