Ramipril

Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

Product Specifications

CAS Number

[87333-19-5]

Product Name Alternative

HOE-498

UNSPSC

12352005

Hazard Statement

H360

Target

Angiotensin-converting Enzyme (ACE) ; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/ramipril.html

Purity

99.33

Solubility

DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1C[C@@](CCC2)([H])[C@@]2([H])N1C([C@@H](N[C@H](C(OCC)=O)CCC3=CC=CC=C3)C)=O)O

Molecular Formula

C23H32N2O5

Molecular Weight

416.51

Precautions

H360

References & Citations

[1]Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22 (3) : p. 611-8.|[2]Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91 (2) : p. 493-7.|[3]Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94 (1) : p. 60-7.|[4]Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21 (6) : p. 423-9.