Ramipril
Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
Product Specifications
CAS Number
87333-19-5
Product Name Alternative
HOE-498
UNSPSC
12352005
Hazard Statement
H360
Target
Angiotensin-converting Enzyme (ACE) ; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ramipril.html
Purity
99.33
Solubility
DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1C[C@@](CCC2)([H])[C@@]2([H])N1C([C@@H](N[C@H](C(OCC)=O)CCC3=CC=CC=C3)C)=O)O
Molecular Formula
C23H32N2O5
Molecular Weight
416.51
Precautions
H360
References & Citations
[1]Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22 (3) : p. 611-8.|[2]Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91 (2) : p. 493-7.|[3]Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94 (1) : p. 60-7.|[4]Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21 (6) : p. 423-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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Available Sizes
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