MG-C-30
MG-C-30 is an orally active agonist for CD27 with an EC50 of 0.84 μM. MG-C-30 activates NK cells and T cell co-stimulatory signals, and enhances immune response. MG-C-30 exhibits antitumor efficacy in mouse EG7-OVA model[1].
Product Specifications
CAS Number
[877164-43-7]
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mg-c-30.html
Purity
95.55
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(OC)C=C(C2=NC(CC(NC(C3=NC4=C(C=CC=C4)N3)C(C)C)=O)=CS2)C=C1
Molecular Formula
C24H26N4O3S
Molecular Weight
450.55
References & Citations
[1]Abdel-Rahman SA, et al., Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints. Sci Adv. 2024 Oct 18;10 (42) :eadq5540.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF7/CD27
Available Sizes
Curated Selection
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