Conantokin R
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].
Product Specifications
CAS Number
202925-60-8
Product Name Alternative
Con-R
UNSPSC
12352209
Target
IGluR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/conantokin-r.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CNC([C@H](CCCCN)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)=O)C(N3[C@@H](CCC3)C(O)=O)=O
Molecular Formula
C127H201N35O49S3
Molecular Weight
3098.35
References & Citations
[1]Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470 (2) :139-46.|[2]White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292 (1) :425-32.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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