BIIB 513
BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load[1].
Product Specifications
CAS Number
265986-98-9
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/biib-513.html
Smiles
O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CO3)=O)CC2)C(S(=O)(C)=O)=C1.CS(=O)(O)=O
Molecular Formula
C19H25N5O8S2
Molecular Weight
515.56
References & Citations
[1]Gumina, et al. "Inhibition of the Na+/H+ exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs." Circulation 100.25 (1999) : 2519-2526.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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