DD205-291
DD205-291 is an orally active PROTAC HPK1 degrader, with a DC50 value of 5.3 nM. DD205-291 inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ expression (Pink: HPK1 protein ligand HY-168283; E3+linker: HY-168284; Blue: E3: HY-W115490; Black: linker: HY-W210252).
Product Specifications
CAS Number
3047066-15-6
UNSPSC
12352005
Target
MAP4K; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dd205-291.html
Smiles
O=C(N1)N(C2=C(C=CC(C(N3CCC(CC3)CC4CCN(CC4)C5=CC=C(C=N5)C6=NC7=C(NC=C7C8=CN(N=C8)CC(F)(F)F)N=C6)=O)=C2)Cl)CCC1=O
Molecular Formula
C38H38ClF3N10O3
Molecular Weight
775.22
References & Citations
[1]Zhang Z, et al. Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy. J Med Chem. 2024 Nov 14;67 (21) :18682-18698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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