Cholestyramine

Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.

Product Specifications

CAS Number

[11041-12-6]

Product Name Alternative

Cholestyramine resin; Colestyramine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Colestyramine.html

Solubility

1 M HCl : < 1 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL

Smiles

C[N+](C)(C)CC1=CC=C(C(CC(C)C2=CC=CC=C2)CC)C=C1.CC(CC)C.[Cl-].[n]

Precautions

H302, H315, H319, H335

References & Citations

[1]Maugeais C, et al. rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment. Atherosclerosis. 2013 Jul;229 (1) :94-101.|[2]Rebecca M. Heidker, et al. Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver. PLoS One. 2016; 11 (4) : e0154305.|[3]J M Pruckler, et al. Use of a human microvascular endothelial cell line as a model system to evaluate cholesterol uptake. Pathobiology. 1993;61 (5-6) :283-7.