Mofarotene
Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells[1][2][3].
Product Specifications
CAS Number
125533-88-2
Product Name Alternative
Ro 40-8757
UNSPSC
12352005
Target
Apoptosis; Caspase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mofarotene.html
Solubility
10 mM in DMSO
Smiles
CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)OCCN4CCOCC4)=CC=C2C(C)(CC1)C)C
Molecular Formula
C29H39NO2
Molecular Weight
433.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Caspase 3; Caspase 9
Available Sizes
Frequently Asked Questions
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