Mitochondrial respiration-IN-4
Mitochondrial respiration-IN-4 (Compound TC11) is a potent mitochondrial respiration inhibitor. Mitochondrial respiration-IN-4 impairs Reactive Oxygen Species (ROS) in and induces apoptosis in MCF7 cells[1].
Product Specifications
UNSPSC
12352005
Target
Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mitochondrial-respiration-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=C(NS(=O)(C5=CC=C(F)C(Cl)=C5)=O)C=C4)=C3)=O)=C1C)NCCN(CC)CC
Molecular Formula
C34H35ClFN5O4S
Molecular Weight
664.19
References & Citations
[1]Helmy SWA, et al. Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells. Eur J Med Chem. 2024 Feb 17;268:116255.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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