Mitochondrial respiration-IN-4

Mitochondrial respiration-IN-4 (Compound TC11) is a potent mitochondrial respiration inhibitor. Mitochondrial respiration-IN-4 impairs Reactive Oxygen Species (ROS) in and induces apoptosis in MCF7 cells[1].

Product Specifications

UNSPSC

12352005

Target

Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mitochondrial-respiration-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=C(NS(=O)(C5=CC=C(F)C(Cl)=C5)=O)C=C4)=C3)=O)=C1C)NCCN(CC)CC

Molecular Formula

C34H35ClFN5O4S

Molecular Weight

664.19

References & Citations

[1]Helmy SWA, et al. Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells. Eur J Med Chem. 2024 Feb 17;268:116255.