2-Iminobiotin (hydrobromide)

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

Product Specifications

CAS Number

[76985-52-9]

Product Name Alternative

Guanidinobiotin (hydrobromide)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-iminobiotin-hydrobromide.html

Purity

98.27

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br

Molecular Formula

C10H18BrN3O2S

Molecular Weight

324.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204 (2) :962-8.|[2]Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.