PTP1B-IN-21
Product Specifications
CAS Number
[3001295-85-5]
UNSPSC Description
PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50>100 μM), which is a key target for type 2 diabetes inhibition[1].
Target Antigen
Phosphatase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ptp1b-in-21.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(C(C3=C(C2=O)C=C(C(CO)=C3O)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O)=O)C=C1
Molecular Weight
462.40
References & Citations
[1]Zhang Z, et al. Selective Inhibition of PTP1B by New Anthraquinone Glycosides from Knoxia valerianoides. J Nat Prod. 2022 Nov 18.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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