RXFP3/4 agonist 2

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM) . RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].

Product Specifications

CAS Number

[2752378-78-0]

UNSPSC

12352005

Target

RXFP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rxfp3-4-agonist-2.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C(C=C1)=CC=C1CCNC(N/N=C/C(C2=CC(C#N)=C3)=CNC2=C3C)=N)=O

Molecular Formula

C22H22N6O2

Molecular Weight

402.45

References & Citations

[1]Guan D, et al. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies. J Med Chem. 2021;64 (24) :17866-17886.