RXFP3/4 agonist 2
RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM) . RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].
Product Specifications
CAS Number
[2752378-78-0]
UNSPSC
12352005
Target
RXFP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rxfp3-4-agonist-2.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC(C(C=C1)=CC=C1CCNC(N/N=C/C(C2=CC(C#N)=C3)=CNC2=C3C)=N)=O
Molecular Formula
C22H22N6O2
Molecular Weight
402.45
References & Citations
[1]Guan D, et al. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies. J Med Chem. 2021;64 (24) :17866-17886.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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