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IDO1-IN-19

Product Specifications

UNSPSC Description

IDO1-IN-19 (Compound 17) is an orally active IDO1 inhibitor with an IC50 of CYP2C9 of 8.64 μM. IDO1-IN-19 also acts funciton on cardiac channels, with IC50s of 12 μM (IKr), 40 μM (INa), 8.3 μM (ICa), respectively. IDO1-IN-19 has the potential to study cancer diseases[1].

Target Antigen

Calcium Channel; Cytochrome P450; Indoleamine 2,3-Dioxygenase (IDO); Potassium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ido1-in-19.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C)(C)C1=CC(C(F)(F)F)=NC=C1C2=CC=C(C3(COC3)C(NC4=CC=C(F)C=C4)=O)C=C2

Molecular Weight

474.45

References & Citations

[1]Derun Li, et al. Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-144652/IDO1-IN-19-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-144652/IDO1-IN-19-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2328099-11-0

Available Sizes

Curated Selection

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