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Anti-Hu CD85h PE

CD85h (leukocyte Ig-like receptor A2) is a type I transmembrane glycoprotein, associating with Fc receptor gamma chain, to serve as an activating immunoreceptor. In the result, however, CD85h signaling leads to suppression of dendritic cell differentiation and antigen presentation, and of innate immune responses. This glycoprotein is expressed mainly on monocytes, macrophages, and myeloid dendritic cells, at a lower level on granulocyte and NK cell subsets.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

Human CD85h transfectants

Target Antigen

CD85h

Clone

24

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL: LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15;179 (12) :8128-36., URL: https://pubmed.ncbi.nlm.nih.gov/18056355/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 24 recognizes an extracellular epitope of CD85h, an approximately 70 kDa transmembrane glycoprotein.

Applications Notes

6

Isotype

Mouse IgG2b kappa

Frequently Asked Questions

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