17-HETE
17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].
Product Specifications
CAS Number
128914-47-6
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/17-hete.html
Concentration
312.04 μM * 500 μL in Ethanol
Purity
98.2
Solubility
10 mM in DMSO
Smiles
CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
Molecular Formula
C20H32O3
Molecular Weight
320.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Isse FA, et al., 17- (R/S) -hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749.|[2]Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271 (4 Pt 2) :R863-9.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
