17-HETE

17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].

Product Specifications

CAS Number

[128914-47-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450; Na+/K+ ATPase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/17-hete.html

Concentration

312.04 μM * 500 μL in Ethanol

Purity

98.2

Solubility

10 mM in DMSO

Smiles

CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O

Molecular Formula

C20H32O3

Molecular Weight

320.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Isse FA, et al., 17- (R/S) -hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749.|[2]Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271 (4 Pt 2) :R863-9.