Centanafadine

Centanafadine is dual norepinephrine (NE) /dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

Product Specifications

CAS Number

[924012-43-1]

Product Name Alternative

EB-1020

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Adrenergic Receptor; Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Centanafadine.html

Purity

99.62

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[C@@H]12[C@@](CNC2)(C3=CC(C=CC=C4)=C4C=C3)C1

Molecular Formula

C15H15N

Molecular Weight

209.29

Precautions

H315, H319, H320

References & Citations

[1]Bymaster FP, et al. Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020: implications for treatment of attention-deficit hyperactivity disorder. Synapse. 2012 Jun;66 (6) :522-32.