Centanafadine
Product Specifications
UNSPSC Description
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.
Target Antigen
Adrenergic Receptor; Dopamine Transporter; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Centanafadine.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
[C@@H]12[C@@](CNC2)(C3=CC(C=CC=C4)=C4C=C3)C1
Molecular Weight
209.29
References & Citations
[1]Bymaster FP, et al. Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020: implications for treatment of attention-deficit hyperactivity disorder. Synapse. 2012 Jun;66(6):522-32.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16736/Centanafadine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16736/Centanafadine-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
924012-43-1
Available Sizes
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