Higenamine (hydrochloride) (Standard)

Higenamine (hydrochloride) (Standard) is the analytical standard of Higenamine (hydrochloride) . This product is intended for research and analytical applications. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6].

Product Specifications

CAS Number

[11041-94-4]

Product Name Alternative

Norcoclaurine (hydrochloride) (Standard)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; MAP3K; MDM-2/p53; Reference Standards; ROS Kinase

Type

Reference Standards

Related Pathways

Apoptosis; MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Infection; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/higenamine-hydrochloride-standard.html

Smiles

OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O.[H]Cl

Molecular Formula

C16H18ClNO3

Molecular Weight

307.77

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorg Chem. 2021 Apr;109:104723. |[2]Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012 May;17 (5) :463-74.|[3]Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Mol Cell Biochem. 2021 Nov;476 (11) :3889-3897.|[4]Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. J Cardiovasc Pharmacol. 2020 Jun;75 (6) :535-544. |[5] Erasto, Paul et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural products and bioprospecting vol. 8,1 (2018) : 63-69. |[6]Dong, Hui et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. 38,5 (2023) : 775-791.