Recombinant Human CCL3
Recombinant human CCL3
Product Specifications
Product Name Alternative
rHuCCL3, MIP-1alpha
Gene Name
CCL3
UniProt
P10147
Cellular Locus
Secreted.
Reactivity
Human
Target Antigen
C-C motif chemokine 3
Target
CCL3
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. RPubMed:8525373}.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration of recombinant CCR5- expressing cells.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/50187P.pdf
Specificity
CCL3
Target Background
CCL3, also known as Macrophage Inflammatory Protein-1a (MIP-1a), is a proinflammatory chemokine that stimulates chemotaxis and activation of different cell populations of the immune system. CCL3 binds to CCR1, CCR4, and CCR5 receptors, and it is one of the major HIV- suppressive factors produced by CD8+ T-cells. CCL3 induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
CAS Number
9000-83-3
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