Dermaseptin-B3
Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively) . Dermaseptin-B3 also inhibits tumor cell proliferation[1][2].
Product Specifications
CAS Number
[210890-55-4]
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dermaseptin-b3.html
Solubility
10 mM in DMSO
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)[C@H](C)C)=O)CC(C)C)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)C)=O)C)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(N)=O)=O)=O)C)=O)CC(C)C)=O)CCCCN)=O)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CC(C)C)=O)CCSC)=O)CC(N)=O)=O)CCCCN)=O)NC([C@@H](NC([C@H](C)N)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2
Molecular Formula
C127H219N35O32S
Molecular Weight
2780.38
References & Citations
[1]Charpentier S, et al. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics. J Biol Chem. 1998 Jun 12;273 (24) :14690-7.|[2]van Zoggel H, et al . Antitumor and angiostatic peptides from frog skin secretions. Amino Acids. 2012 Jan;42 (1) :385-95.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5580/Dermaseptin-B3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5580/
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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