ATR-IN-30
ATR-IN-30 is a selective ATR ligand, and can be used for synthesis of ATR PROTACs, such as PROTAC ATR degrader-2.
Product Specifications
CAS Number
3010273-13-6
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-30.html
Smiles
O=C(C1=NC(C2=CC=C(C(N3CCN(C(OC(C)(C)C)=O)CC3)=O)C=C2)=CN=C1N)NC4=CC=CC=C4
Molecular Formula
C27H30N6O4
Molecular Weight
502.56
References & Citations
[1]Wang Y, et al. Discovery of Selective and Potent ATR Degrader for Exploration its Kinase-Independent Functions in Acute Myeloid Leukemia Cells. Angew Chem Int Ed Engl. 2024 Apr 22;63 (17) :e202318568.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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