AT7867
Product Specifications
UNSPSC Description
AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
Target Antigen
Akt; PKA; Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AT7867.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4
Molecular Weight
337.85
References & Citations
[1]Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12059/AT7867-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12059/AT7867-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
857531-00-1
Available Sizes
Curated Selection
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