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SB-258585 (hydrochloride)

SB-258585 is a high affinity ligand for the 5-HT6 receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT6 receptors. SB-258585 can be used to label recombinant and natural 5-HT6 receptor [1].

Product Specifications

CAS Number

[1216468-02-8]

UNSPSC

12352005

Hazard Statement

H315-H319-H334-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-258585-hydrochloride.html

Purity

99.72

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O.Cl

Molecular Formula

C18H23ClIN3O3S

Molecular Weight

523.82

Precautions

P261-P264-P271-P280-P284-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hirst WD, et al. Characterization of [ (125) I]-SB-258585 binding to human recombinant and native 5-HT (6) receptors in rat, pig and human brain tissue. Br J Pharmacol. 2000 Aug;130 (7) :1597-605.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT6 Receptor

Available Sizes

Curated Selection

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