Sonidegib
Product Specifications
UNSPSC Description
Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].
Target Antigen
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lde225.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4
Molecular Weight
485.50
References & Citations
[1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.bioRxiv. 2023 Nov 6.|bioRxiv. 2024 Jul 25.|bioRxiv. 2024 Oct 9:2024.10.08.617155.|Cell Physiol Biochem. 2018;47(4):1352-1364.|J Genet Genomics. 2018 May 20;45(5):237-246.|Nat Med. 2018 Nov;24(11):1752-1761. |Patent. US20180263995A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16582A/Sonidegib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16582A/Sonidegib-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
956697-53-3
Available Sizes
Curated Selection
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