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Androgen receptor allosteric antagonist 1

Androgen receptor allosteric antagonist 1 (compound D36) is a a llosteric, competitive androgen receptor (AR) antagonist with the Ki of 9 μM. Androgen receptor allosteric antagonist 1 inhibits R1881-mediated transcription and proliferation and can be used for study of prostate cancer[1].

Product Specifications

CAS Number

927819-39-4

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/androgen-receptor-allosteric-antagonist-1.html

Smiles

O=C(CC1=CN(CC(C)C)C2=CC=C(C3=C(OC)C=CC=C3)C=C21)N

Molecular Formula

C21H24N2O2

Molecular Weight

336.43

References & Citations

[1]Joseph JD, et al. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proc Natl Acad Sci U S A. 2009;106 (29) :12178-12183.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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