CYC-116
Product Specifications
UNSPSC Description
CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.
Target Antigen
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CYC-116.html
Purity
98.17
Solubility
DMSO : 15 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2
Molecular Weight
368.46
References & Citations
[1]Wang S, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10558/CYC-116-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10558/CYC-116-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
693228-63-6
Available Sizes
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