CYC-116

CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

Product Specifications

CAS Number

[693228-63-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CYC-116.html

Purity

99.05

Solubility

DMSO : 15 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2

Molecular Formula

C18H20N6OS

Molecular Weight

368.46

Precautions

H315, H319, H320

References & Citations

[1]Wang S, et al. Discovery of N-phenyl-4- (thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53 (11) :4367-78.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Aurora A; Aurora B

Available Sizes

Curated Selection

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