CYC-116
CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.
Product Specifications
CAS Number
[693228-63-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CYC-116.html
Purity
99.05
Solubility
DMSO : 15 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2
Molecular Formula
C18H20N6OS
Molecular Weight
368.46
Precautions
H315, H319, H320
References & Citations
[1]Wang S, et al. Discovery of N-phenyl-4- (thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53 (11) :4367-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Aurora A; Aurora B
Available Sizes
Curated Selection
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