VU 0357121
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes[1].
Product Specifications
CAS Number
[433967-28-3]
UNSPSC
12352005
Hazard Statement
H400, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU-0357121.html
Purity
99.73
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(NC1=CC=C(F)C=C1F)C2=CC=C(OCCCC)C=C2
Molecular Formula
C17H17F2NO2
Molecular Weight
305.32
Precautions
H400, H410
References & Citations
[1]Hammond. Alexis S, et al. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chemical Neuroscience (2010), 1 (10), 702-716.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
Curated Selection
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