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VU 0357121

VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes[1].

Product Specifications

CAS Number

433967-28-3

UNSPSC

12352005

Hazard Statement

H400, H410

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/VU-0357121.html

Purity

99.73

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NC1=CC=C(F)C=C1F)C2=CC=C(OCCCC)C=C2

Molecular Formula

C17H17F2NO2

Molecular Weight

305.32

Precautions

H400, H410

References & Citations

[1]Hammond. Alexis S, et al. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chemical Neuroscience (2010), 1 (10), 702-716.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR5

Available Sizes

Frequently Asked Questions

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