SLM6031434 (hydrochloride)
SLM6031434 hydrochloride is the hydrochloride salt form of SLM6031434 (HY-120268) . SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC50 value of 0.4 μM for SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO) -induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD) [1][2].
Product Specifications
CAS Number
[1897379-34-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/slm6031434-hydrochloride.html
Purity
99.1
Solubility
H2O : 40 mg/mL (ultrasonic; warming)
Smiles
N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl
Molecular Formula
C22H31ClF3N5O2
Molecular Weight
489.96
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1; SphK2
Available Sizes
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