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SLM6031434 (hydrochloride)

Product Specifications

UNSPSC Description

SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].

Target Antigen

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/slm6031434-hydrochloride.html

Purity

99.1

Solubility

H2O : 40 mg/mL (ultrasonic;warming)

Smiles

N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl

Molecular Weight

489.96

References & Citations

[1]Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-120268A/SLM6031434-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-120268A/SLM6031434-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1897379-34-8

Available Sizes

Curated Selection

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