Dicyclomine

Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].

Product Specifications

CAS Number

[77-19-0]

Product Name Alternative

Dicycloverine

UNSPSC

12352211

Hazard Statement

H302

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dicyclomine.html

Purity

90.00

Solubility

10 mM in DMSO

Smiles

O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC

Molecular Formula

C19H35NO2

Molecular Weight

309.49

Precautions

P264-P270-P330-P501

References & Citations

[1]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[2]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020. |[3]Susan J Bartko, et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl) . 2011 Mar;214 (2) :537-48.